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中文摘要：
目的：研究去水淫羊藿素（ICT）对大鼠局灶性脑缺血再灌注损伤的保护作用，并初步探讨其保护作用是否与抗氧化应激有关。方法：采用大鼠大脑中动脉栓塞，制作局灶性脑缺血再灌注损伤模型，缺血后10 min，于腹腔注射溶剂、依达拉奉及不同剂量的ICT。栓塞2 h，再灌注24 h后，腹主动脉取血，分离血清，断头取脑，TTC染色，检测脑梗死范围。比色法检测血清超氧化物歧化酶（SOD）、谷胱苷肽过氧化物酶（GSH-Px）的活性及丙二醛（MDA）、一氧化氮（NO）的含量。结果：与模型组相比，各剂量的ICT治疗组脑梗死范围减小；血清MDA和NO含量降低，SOD和GSH-Px的活性显著升高。结论：ICT对脑缺血再灌注损伤具有保护作用，其机制与ICT提高抗氧化作用，抑制缺血再灌注损伤引起的氧化应激有关。
英文摘要：
Objective：To explore the therapeutic effects of Icaritin （ICT）on cerebral ischemia-reperfusion injury and ob-serve its antioxidation mechanism.Methods：Focal cerebral ischemia-reperfusion injury model was made through emboli-zation of the middle cerebral artery of rats.The injury was treated with solvent,edaravone and different doses of ICT by intraperitoneal injection 10 min after the ischemia.24 h after reperfusion,blood was got from the abdominal aorta;serum was separated;the rat was beheaded to get brain;the cerebral tissue was stained by TTC;the range of cerebral infarction was detected.Moreover,the activities of superoxide dismutase （SOD）,glutathione peroxidase （GSH-Px）,the levels of malonaldehyde（MDA）and nitric oxide（NO）in serum were measured.Results：After treatment,a reduction in the vol-ume of infarction and an elevation in the activities of SOD and GSH-Px in serum were observed.The decrease in MDA and NO levels in serum were also observed.Conclusion：ICT has protective effects on cerebral ischemia-reperfusion inju-ry because it enhances the antioxidation and then inhibits oxidative stress.
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