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中文摘要：
目的探讨血清胱抑素C（Cys-C）,叶酸（FA）、维生素B（12）（Vit B（12））联合检测慢性肾脏病的临床应用价值。方法选择2015年3月—2016年5月在我院内科两个病区住院的慢性肾脏病患者97例,根据患者透析情况分为透析组54例和非透析组43例。2组均采用胶乳免疫比浊法测定血清Cys-C浓度和电化学发光法检测血清FA、Vit B（12）含量并进行比较。结果透析组第30,90天血清Cys-C、FA、Vit B（12）含量与非透析组比较差异均有统计学意义（P〈0.01）。透析组低叶酸血症发生率29.63%,非透析组为4.65%,2组比较差异有统计学意义（P〈0.01）。结论慢性肾脏病透析患者血清Cys-C升高,血清FA、Vit B（12）含量降低。血清Cys-C、FA、Vit B（12）联合检测是反映慢性肾脏病较敏感的生物学标志物,可以作为病情和预后评估的指标。
英文摘要：
Objective To investigate the change of the serum cystatin C （Cys-C）, folic acid （FA）, vitamin B12 （Vit BI2） content level and its clinical significance in patients with chronic kidney disease.Methods From March 2015 to May 2016,97 patients with chronic kidney disease in the Department of medicine of Huishui County People＇s Hospital of Guizhou Province were divided into dialysis group （n=54） and non dialysis group （n=43）.Two groups were determined by latex immunoassay turbidimetry Cys-C concentration of serum and electrochemil detection of serum FA,Vit B12eontent and its make statistical analysis.Results The levels of serum Cys-C,FA and Vit B12 in the dialysis group were significantly different from those in the non dialysis group at 30 and 90 days （P〈0.01）.The incidence of folio acid in the dialysis group was 29.63% ,The incidence of folic acid in the non dialysis group was 4.65% ,The difference between the two groups was statistically significant （P〈0.01）.Conclusion The level of serum Cys-C in patients with chronic kidney disease was increased, and the level of serum FA and Vit B12 were decreased.Serum Cys-C, FA, Vit Bl2 is a sensitive biomarker of chronic kidney disease, which can be used as an indicator to evaluate the condition and prognosis of patients with chronic kidney disease.
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