中文摘要：

目的观察神经外科脑肿瘤患者围术期血小板（PLT）计数及凝血-纤溶系统相关指标的动态变化。方法收集北京天坛医院神经外科住院脑肿瘤患者共73例,分别于术前、术后第1天、术后第3天采集空腹静脉血标本,检测PLT计数、血浆D-二聚体及纤维蛋白原（FIB）水平,并与健康对照组（n=30）进行比较,分析其变化情况。结果脑肿瘤患者术前PLT水平低于健康对照组,但差异无统计学意义（P〉0.05）,而术前D-二聚体及FIB水平较健康对照组明显升高（P〈0.05）。开颅术后第1天,PLT计数与FIB水平均较术前明显下降,而D-二聚体水平显著升高（P〈0.05）。术后第3天PLT计数仍较术前下降,FIB呈回升趋势,与术前相比差异无统计学意义（P〉0.05）;而D-二聚体仍维持较高水平,但与术后第1天相比呈下降趋势（P〈0.05）。结论脑肿瘤患者围术期存在凝血及纤溶功能异常,严密监测围术期凝血及纤溶相关指标对早期发现静脉血栓等术后并发症有重要价值。

英文摘要：

Objective To observe dynamic changes of platelet（PLT）count and coagulation fibrinolysis system in patients with cerebroma during perioperative period in department of neurosurgery.Methods A total of 73 patients with brain tumor were collected from department of neurosurgery,Beijing Tiantan Hospital.Fasting venous blood samples were collected before operation,first day and third day after operation.PLT counts,plasma D-dimer and FIB levels were detected,and compared with healthy control group,the changes were analyzed.Results The level of preoperative PLT in patients with brain tumor was lower than that in healthy control group,but the difference was not statistically significant（P〉0.05）,the level of D-dimer and FIB were significantly higher than that of the healthy control group（P〈0.05）.On the first day after craniotomy,PLT counts and FIB levels were significantly decreased,while D-dimer level was significantly increased（P〈0.05）.At third day after craniotomy,the level of PLT was still lower than that of preoperation,FIB showed a trend of recovery,and there was no significant difference compared with that preoperation（P〉0.05）.The D-dimer remained at a high level,but it was in a downward trend compared with first day after craniotomy（P〈0.05）.Conclusion There is an abnormal blood coagulation and fibrinolysis in patients with brain tumor during perioperative period,and it is important to monitor the blood coagulation and fibrinolysis indexes closely during perioperative period.