目的:探讨尖叶假龙胆醇提液对心肌缺血再灌注损伤模型大鼠血清中TXB_2和6-酮-PGF1α的影响。方法:将大鼠制备心肌缺血再灌注损伤模型,用尖叶假龙胆醇提液进行干预,检测大鼠血清中TXB_2和6-酮-PGF1α的含量变化。结果:尖叶假龙胆醇提液能显著降低MIRI模型大鼠血清中TXB_2的含量,6-酮-PGF1α的含量升高。结论:尖叶假龙胆具有舒张血管、抗血小板聚集的作用,可以减轻心肌缺血再灌注损伤。
Objective: To discuss the effect on TXB_2 and 6-keto-PGF1α from the serum of MIRI rats by Gentianella Acuta extracted fluid by Alcohol. Methods: Prepare the rat models with myocardial ischemia reperfusion injury,with the intervention of alcohol extraction of Gentianella acuta. Determine the changes of TXB_2 and 6-keto-PGF1α from rats' serum. Results: Gentianella acuta alcohol extraction could significantly reduce the contents of TXB_2 from the serum of MIRI rat models,but could increase the contents of 6-keto-PGF1α. Conclusion: Gentianella acuta has an inhibitory effect on platelet aggregation,vascular,which can reduce myocardial ischemia reperfusion injury.