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中文摘要：
目的：探讨干眼患者使用表面麻醉剂后泪河的变化。方法：随机选取干眼患者50例。随机选取一眼滴用表面麻醉剂纳入试验组,另一眼用9g/L生理盐水点眼纳入对照组,点药15min后通过眼前节相干光学断层扫描仪（anterior segment optical coherence tomography,AS-OCT）记录并比较两组的泪河高度（tear meniscus height,TMH）、泪河深度（tear meniscus depth,TMD）以及泪河横截面面积（tear meniscus area,TMA）。结果：表面麻醉剂使用后TMH为0.173±0.040mm,TMD为0.166±0.019mm,TMA为0.049±0.013mm2,与点药前相比,差异均有统计学意义（tTMH=2.78,P〈0.01;tTMD=2.31,P〈0.01;tTMA=2.69,P〈0.01）,点药后两组相比,差异均有统计学意义（tTMH=5.87,P〈0.01;tTMD=2.04,P〈0.05;tTMA=4.63,P〈0.01）。结论：表面麻醉剂减少干眼患者泪液分泌量,临床工作中应加强预防和干预。
英文摘要：
AIM：To investigate the change of tear meniscus after using topical anesthetics on tear meniscus in dry eyes patients.METHODS：Fifty cases with dry eyes were chosen in this clinical trial.They were randomly divided into two groups,one group as the experimental group,using topical instillation;another group as the control group,with 9g/L saline instillation.After 15 min,anterior segment optical coherence tomography（AS-OCT） was used to measure tear meniscus height（TMH）,tear meniscus depth（TMD） and tear meniscus area（TMA）before and after treated with topical anesthetics eye drops,and the changes were compared.RESULTS：After treated with topical anesthetics eye drops,the value of TMH was 0.173±0.040mm;TMD was0.166 ±0.019mm;TMA was 0.049 ±0.013mm^2.They were significant different from the values before treated with topical anesthetics（tTMH =2.78,P〈0.01;tTMD） =2.31,P0.01;tTMA = 2.69,P 〈0.01）.After treated with topical anesthetics eye drops and saline instillation,the value of TMH TMD,TMA were different between two groups（tTMH =5.87,P〈0.01;tTMD=2.04,P〈0.05;tTMA =4.63,P〈0.01）.CONCLUSION：Topical anesthetics can effectively relieve the tear meniscus in patients with dry eyes,which need to arouse awareness in clinical work.
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