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中文摘要：
目的探讨血浆 NT-proBNP 在急性心力衰竭（AHF）早期诊治及预后评估中的应用价值。方法选取2014年1月至2015年12月在广州中医药大学附属佛山中医院急诊科就诊的 AHF患者127例（男性53例，女性74例，年龄45～93岁）作为研究对象，按 NYHA 分级方案将患者分为4组：心功能Ⅰ级组、心功能Ⅱ级组、心功能Ⅲ级组和心功能Ⅳ级组。比较观察各组 AHF 患者其血浆NT-proBNP 与左心室射血分数（LVEF）、主要不良心血管事件（MACE）发生情况的关系。结果AHF患者血浆 NT-proBNP 升高程度与 NYHA 心功能分级呈正相关，与 LVEF 呈负相关；治疗1周后血浆NT-proBNP 下降幅度与 NYHA 心功能分级、MACE 发生情况呈负相关。结论血浆 NT-proBNP 在AHF 患者的早期诊治和预后评估中具有临床指导意义。
英文摘要：
Objective To explore the application value of plasma NT-proBNP in early diagnosis and treatment and prognostic assessment for acute heart failure (AHF)patients.Methods Total 1 27 cases of AHF patients were collected in the Emergency Department of our hospital between January 201 4 and December 201 5.These cases were divided into 4 groups according to the NYHA classification of cardiac function:cardiac function grade Ⅰ group,cardiac function grade Ⅱ group,cardiac function grade Ⅲ group and cardiac function grade Ⅳ group.The relationship was o observed between plasma NT-proBNP,left ventricular ejection fraction (LVEF)and the happening of the major adverse cardiovascular events (MACE) in the AHF patients of different cardiac function grade groups.Results The increased level of plasma NT-proBNP was positively related to the NYHA classification of cardiac function,negatively related to LVEF;the reduced level of plasma NT-proBNP after the treatment for 1 week,was negatively related to the NYHA classification of cardiac function and the happening of MACE.Conclusion Plasma NT-proBNP has important value in early diagnosis and treatment and prognosis assessment for acute heart failure patients.
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