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高磷酸化胰岛素样生长因子结合蛋白-1与宫颈长度在预测早产中的应用研究

ISSN号：1006-6586
期刊名称：《中国医疗器械信息》
时间：0
分类：R714.21[医药卫生—妇产科学;医药卫生—临床医学]
作者机构：阳江市人民医院,广东阳江529500
相关基金：阳江市卫生计生局科研项目（2015001）

作者：陈劲

关键词：高磷酸化胰岛素样生长因子结合蛋白-1, 宫颈长度, 早产, High phosphate, Insulin like growth factor binding protein - 1 , Cervical length, Premature delivery

中文摘要：

目的探讨高磷酸化胰岛素样生长因子结合蛋白-1联合宫颈长度在预测早产中的应用价值,为临床的诊治提供参考。方法回顾性分析150例自2013年1月至2015年1月期间在我院就诊具有早产风险孕妇的临床资料,将发生早产的38例孕妇分为A组,将未发生早产的112例孕妇分为B组。对比两组孕妇的高磷酸化胰岛素样生长因子结合蛋白-1和宫颈长度的检查结果。分析高磷酸化胰岛素样生长因子结合蛋白-1、宫颈长度检查以及两者联合检测等三种方法预测早产的敏感度、特异度、阳性预测值和阴性预测值。结果 A组高磷酸化胰岛素样生长因子结合蛋白-1的阳性率为60.53%,显著高于B组（P〈0.05）;A组的宫颈长度为（3.26±0.51）cm,显著低于B组（P〈0.05）;高磷酸化胰岛素样生长因子结合蛋白-1预测早产的敏感度为60.53%,特异度为93.75%,阳性预测值为76.67%,阴性预测值为87.50%;宫颈长度预测早产的敏感度为86.84%,特异度为79.46%,阳性预测值为58.93%,阴性预测值为94.68%;两者联合检测预测早产的敏感度为92.11%,特异度为95.54%,阳性预测值为87.50%,阴性预测值为97.27%。结论高磷酸化胰岛素样生长因子结合蛋白-1联合宫颈长度对早产的发生有良好的预测价值,可指导临床制定早产防治策略。

英文摘要：

Objective To investigate the application value of the combination of high phosphorus and acid insulin like growth factor binding protein - 1 and cervical length in the prediction of premature delivery, and to provide a reference for clinical diagnosis and treatment. Methods 150 pregnant women with premature delivery were analyzed, 38 cases of premature delivery were selected as group A, and 112 cases of premature delivery were selected as group B. The examination results of high phosphorylation of insulin like growth factor binding protein - 1 and the cervical length were compared between the two groups. The detections of the level of insulin like growth factor binding protein, - 1, cervical length and combined detection were used to analyze the sensitivity, specificity, posi- tive predictive value and negative predictive value. Results The positive rate of high phosphorus and acid insulin like growth factor binding protein - 1 in group A was 60.53% , which was significantly higher than that of group B （ P 〈0.05） ; The cervical length of group A was （3.26±0.51 ） cm, which was significantly lower than that of group B. The sensitivity of high phosphorus and acid insuli, like growth factor binding protein - 1 on prediction of premature delivery was 60.53%, the specificity was 93.75%, the positive pre-dictive was 76.67% , and the negative predictive value was 87.50% ; For the cervical length, the sensitivity was 86.84% , the speci-ficity was 79.46%, the positive predictive was 58.93%, and the negative predictive value was 94.68% ; For the combination the sen- sitivity was 92. 11% , the specificity was 95.54% , the positive predictive was 87.50% , and the negative predictive value was 97. 27%, respectively. Conclusion The combination of high phosphorus and acid insulin like growth factor binding protein - 1 and the cervical length has good predictive value, which can guide the clinical treatment of premature delivery.

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