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中文摘要：
引言 琥珀酸（succinic acid）是一种重要的四碳平台化合物，广泛应用于医药、农药、染料、香料、油漆、食品、塑料和照相材料工业。发酵法生产琥珀酸以可再生碳源（如葡萄糖等）和二氧化碳作为主要原料，不仅可以摆脱对石化原料的依赖，而且提供了利用温室气体二氧化碳的新途径，被认为是一个新兴的、很有发展潜力的绿色工艺，成为近年来国内外的研究热点。
英文摘要：
In this work, the semi-continuous succinic acid fermentation by Actinobacillus succinogenes CGMCC1593 from cane molasses with a novel two-stage and two-stream system was studied, in order to increase the succinic acid productivity.The fermentation conditions of the first stage, such as initial sugar concentration, medium addition volume, and time interval of each loading were optimized.Under the optimized condition the maximum succinic acid productivity （2.38 g·L^-1·h^-1） was increased by 111% and 114% compared with those obtained in batch and fed batch fermentation, respectively.In addition, the maximum succinic acid concentration （46.0 g·L^-1）increased by 12.9% compared with that in batch fermentation, and reached a compatible level of that obtained in fed batch fermentation （36 h, 48.8 g·L^-1）.This process was operated stably for 39 circles without any decreases in both succinic acid concentration and productivity.During the 39 operation circles, the fermentation time of each batch （stage 1 and stage 2）, the average succinic acid concentration, succinic acid productivity, succinic acid yield, and sugar conversion rate were 21—24 h, 43.5 g·L^-1, 2.07 g·L^-1·h^-1, 0.79 g·g^-1, and 96.4%, respectively.
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