当离子通道能够被构形地描述为连续时间可逆Markov链时,考虑怎样确定其转移速率.结果发现全部的转移速率能够由两相邻状态的生存时间和死亡时间的分布唯一确定,对此给出了相应的算法.
It is considered how to determine all transition rates of ionic channel when it can be conformationally described by a reversible cyclic Markov chain with continuous time. It is found that all transition rates are uniquely determined by the distributions of their lifetime and death-time at two neighboring states. An algorithm to exactly calculate all transition rates is developed.