中文摘要：

目的：分析胃病患者幽门螺杆菌（Hp）感染及其对常规治疗药物的耐药性，为临床防治提供依据。方法选择医院2012年6月－2014年6月收治的419例胃病患者为研究对象，调查其幽门螺杆菌感染现状，分析其耐药性。结果419例胃病患者中H p感染172例，感染率为41．1％；H p感染以胃溃疡患者最高为54．8％、其次为十二指肠球炎为53．1％、十二指肠球部溃疡为42．7％、慢性浅表性胃炎为35．4％、复合性溃疡为33．3％和胃癌为25．0％；H p对甲硝唑、克拉霉素、左氧氟沙星、阿莫西林、庆大霉素、呋喃唑酮和四环素的耐药率分别为86．6％、31．4％、12．2％、5．8％、1．2％、0和0。结论胃病患者 Hp感染率较高，Hp对呋喃唑酮和四环素未检出耐药菌株，可作为首选药物；Hp对阿莫西林和庆大霉素有较弱的耐药性，可作为备用药物；Hp对甲硝唑具有较高耐药性，临床应避免选用。

英文摘要：

OBJECTIVE To investigate the prevalence of Helicobacter pylori infections in the patients with gastric diseases and analyze the drug resistance to the commonly used antibiotics so as to provide guidance for clinical pre‐vention and treatment .METHODS A total of 419 patients with gastric diseases who were treated in the hospital from Jun 2012 to Jun 2014 were recruited as the study objects ,then the prevalence of H .pylori infection was in‐vestigated ,and the drug resistance was analyzed .RESULTS Of 419 patients with gastric diseases ,172 had the H . pylori infection with the infection rate of 41 .1% ;the incidence of H .pylori infection was 54 .8% in the patients with gastric ulcer ,53 .1% in the patients with duodenal bulbar inflammation ,42 .7% in the patients with duodenal ulcer ,35 .4% in the patients with chronic superficial gastritis ,33 .3% in the patients with complex ulcer ,and 25 .0% in the patients with gastric cancer .The drug resistance rates of the H .pylori to metronidazole ,clarithro‐mycin ,levofloxacin ,amoxicillin ,gentamicin ,furazolidone ,and tetracycline were 86 .6% ,31 .4% ,12 .2% , 5 .8% ,1 .2% ,0 ,and 0 ,respectively .CONCLUSION The incidence of H .pylori infection is high in the patients with gastric diseases .The H .pylori strains are not found to be resistant to furazolidone and tetracycline ,which are preferred for the treatment of H .pylori infections ;the drug resistance rates of the H .pylori to amoxicillin and gentamicin are relatively low ,and they can be used as alternatives ;the use of metronidazole should be avoided due to the high drug resistance of the H .pylori .