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中文摘要：
胍丁胺是一种新的神经递质和/或神经调质,是咪唑啉受体的内源性配体.它作为一种阳离子胺类物质,除了咪唑啉受体外,在生物体内还存在多个作用靶点,NMDA受体是其中最重要的作用靶点之一.本文就胍丁胺与NMDA受体在中枢神经系统的分布、胍丁胺在NMDA受体上的作用位点以及胍丁胺通过NMDA受体介导的药理作用等几个方面进行了综述.
英文摘要：
Agmatine is a novel neurotransmitter and/or neuromodulator, which is the endogenic ligand of the imidazoline receptors. As an amine and organic cation, agmatine also has much more targets in vivo like the NMDA receptor. This review will summarize several aspects concerning the distribution of agmatine and NMDA receptors in the central nervous system （CNS）, the binding sites of agmatine on NMDA receptors as well as the pharmacological functions closely associated with NMDA receptors.
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