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中文摘要：
目的评价由卡铂（CBP）＋氟脲嘧啶（5-FU）组成的PF化疗方案联合放疗治疗中晚期鼻咽癌的疗效和毒副反应。方法60例Ⅲ、Ⅳ期鼻咽癌患者随机分为化学治疗（化疗）＋放疗组（A组）和单纯放疗组（B组），每组30例。A组于放疗前诱导化疗1～2个疗程，放疗结束后辅助化疗2～3个疗程。两组放疗方法相同，鼻咽部剂量65～80Gy／5．5～7周，颈部剂量50～82Gy／4．5～7．5周。结果A组及B组治疗结束后2个月鼻咽部肿瘤完全消退率分别为77％和73％（P〉0．05），颈淋巴结转移灶完全消退率分别为92％和64％（P〈0．05）。A组毒性反应较B组重。结论PF方案联合放疗可显著提高中晚期鼻咽癌患者的近期疗效，但加用化疗同时也增加了毒性反应。
英文摘要：
Objective To evaluate the result and the poisonous side reaction of CBP ＋ 5-FU （PF） regimen chemotherapy plus radiotherapy for treating phase Ⅲ,Ⅳ nasopharyngeal cancer. Methods 60 cases of phase Ⅲ,Ⅳ nasopharyngeal cancer were divided into two groups randomly, one was chemotherapy plus radiotherapy. The other was radiotherapy alone. PF regimen were used in the chemo-radiotherapy group before and after the end of radiotherapy, 1 -2 and 2- 3 cycles of chemotherapy were finished. The radiotherapy methods were the same in the two groups. The dosage in the nasopharyngeal part was 65 - 80Gy/5.5 - 7 weeks and the metastatic cervical lymphnodes was 50 - 82Gy/4.5-7.5 weeks. Results Two months after the end of the treatment, the complete retrogression rates of nasopharyngesl cancer were 77 % and 73 % respectively（ P 〉 0.05）, and of metastatic cervical lymphnodes were 92 % and 64 % respectively（ P 〈 0.05 ） in the chemo-radiotherapy group and radiotherapy alone group. Conclusion PF regimen plus radiotherapy can significantly improve the local disease control rate of Ⅲ,Ⅳ nasopharyngeal cancer patients, but the adding of chemotherapy increased the toxicity at the same time.
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