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中文摘要：
目的探讨Infliximab（TNF-a单抗）对急性坏死性胰腺炎（ANP）并多器官功能障碍（MODS）模型大鼠肝损害的防治效应。方法经胰胆管逆行注射4.5%牛磺胆酸钠制备大鼠ANP并MODS模型。40只SD大鼠随机分为手术对照组、模型组和Infliximab治疗组、Octreotide治疗组、Infliximab＋Octreotide治疗组。其中,各治疗组于建模后6小时注射药物。建模后24小时处死大鼠,分别检测血清TNF-α、淀粉酶（AMS）、总胆红素（TB）,以及胰腺、肝组织病理等指标。结果各治疗组AMS、TNF-α、ALT、TB及胰腺、肝组织病理评分较建模组均显著降低（P〈0.05）。Infliximab＋Octreotide治疗组AMS、TNF-α、ALT、TB及胰腺、肝组织病理评分较Infliximab组及Octreotide组降低更为显著（P〈0.05）。结论早期使用Infliximab单抗可显著降低ANP并MODS模型的TNF-α水平,对肝损害具有显著的防治效应。Infliximab和Octreotide联用可显著提高Infliximab对ANP并MODS模型肝肾损害的疗效。
英文摘要：
Objective To study of therapeutic role of infliximab on the liver injury in rats model with acute necrosis pancreatitis complicating MODS.Methods ANP complicating MODS animal model was induced by retrograde injection into rat＇s biliopancreatic duct with 4.5% of NaTc solution.40 female SD rats were randomly divided into control group,ANP model group,Infliximab treated group,Octretide treatd group,and Infliximab＋Octretide treated group.The treated group was injected Infliximab or Octretide via caudal vein in 6 hours after established the animal model.The rats of each group were observed and sacrificed at 24h after the models were induced.Serum AMS level,TNF-α,serum ALT,serum TB,pancreatitis and liver pathomorphologic score of rats were determined.Results The AMS level,TNF-α,serum ALT,serum TB,pancreatitis and liver pathomorphologic score of the treated group were significant lower than the model group（P0.05）.The Infliximab＋Octretide treated group was significant lower than the Infliximab or Octretide treated group（P0.05）.Conclusion The early use of Infliximab can significantly reduce the TNF-α level in ANP complicating MODS model,and has significant effects in liver injure.Infliximab ＋ Octreotide can significantly increase the efficacy of Infliximab to liver injure in ANP complicating MODS model.
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