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中文摘要：
采用离心超滤质谱技术从川乌总生物碱提取物中筛选与人血清白蛋白相互作用的乌头类生物碱成分, 并用LC-MSn技术对筛选出的活性成分进行了分离鉴定. 结果表明, 从川乌总生物碱中筛选并鉴定出9种与人血清白蛋白存在相互作用的乌头类生物碱： 苯甲酰新乌头原碱、苯甲酰乌头原碱、10-OH-中乌头碱、中乌头碱、10-OH-乌头碱、乌头碱、次乌头碱、脱氧乌头碱和3,13-脱氧乌头碱.
英文摘要：
A ultrafiltration LC-MS screening assay was developed for the screening and structures characterization of human serum albumin（HSA） ligands from the alkaloids extract of Radix aconiti. As a result, 9 compounds that can bind to HSA were found and were identified as 14-benzoylmesaconine, 14-benzoylaconine, 10-OH-mesaconitine, mesaconitine, 10-OH-aconitine, aconitine, hypaconitine, deoxyaconitine and 3,13-deoxyaconitine by ESI-MS^n data .
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Bioactivity fingerprint analysis of cyclooxygenase-2 ligands from radix Aconiti by ultrafiltration-U
ABSORPTION OF HYPACONITINE AND P-GLYCOPROTEIN-MEDIATED DRUG-HYPACONITINE INTERACTIONS BY CACO-2 HUMA
Study on the Metabolic Characteristics of Aconite Alkaloids in the Extract of Radix aconiti under In
Fingerprint analysis of Radix Aconiti using ultra-performance liquid chromatography-electrospray ion
Rapid quality assessment of Radix Aconiti Preparata using direct analysis in real time (DART) mass s
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