中文摘要：

试验旨在阐明蛹虫草多糖（CMP）对小鼠抗氧化活性的影响。选取90只雄性 BALB/c 小鼠,体重18-20 g,随机分为6组,3个 CMP 组（低、中、高 CMP 组）,模型对照组（CY 组）、阳性对照组（PC 组）及空白对照组（BC组）各1个。CMP 组和 CY 组分别腹腔注射80 mg/kg 环磷酰胺,连续3 d,然后3个 CMP 组分别灌胃给予17.5、35.0、70.0 mg/kg 体重的 CMP,BC 组和 CY 组给予生理盐水,PC 组灌胃给予70 mg/kg 体重的 CMP,持续18 d。于最后一次给药24 h 后,采集小鼠内脏,测定心脏、肝脏及肾脏匀浆液中 T-AOC、MAD、CAT、SOD 和 GSH-Px 水平。结果显示,与 CY 组相比,3个 CMP 处理组小鼠内脏匀浆液中的 SOD 和 T-AOC 活性均极显著增加（P 〈0.01）,MDA 水平极显著降低（P 〈0.01）；低剂量 CMP 组心脏 CAT 无显著变化（P 〉0.05）,中、高剂量 CMP 组心脏 CAT 水平分别显著（P 〈0.05）、极显著（P 〈0.01）提高；除低剂量 CMP 组肝脏 GSH-Px 活性显著增加（P 〈0.05）外,其余 CMP 组内脏 GSH-Px 活性均极显著增加（P 〈0.01）。本试验中 CMP 可以有效提高小鼠心脏、肝脏及肾脏的抗氧化活性,这为抗氧化新药的研发提供了借鉴。

英文摘要：

To investigate the antioxidant effects of the Cordyceps militaris polysaccharides （CMP）,90 male BALB/c mice were randomly divided into six groups,three experimental groups （CMP groups）,model control group （CY group）,blank control group （BC group）and positive control group （PC group）.The mice in CMP and CY groups were given cyclophosphamide at 80 mg/kg via intraperitoneal injection for 3 d.Then the CMP groups were administrated 17.5, 35.0 and 70.0 mg/（kg＆#183;BW）CMP via gavage,respectively,BC and CY groups were given phys-iological saline,and PC group was orally administered 70 mg/（kg＆#183;BW）CMP,lasting 18 d.At 24 h after the last administration,heart,liver and kidney were collected to measure the levels of MAD,CAT,SOD,GSH-Px and T-AOC in the homogenate.SOD and TAOC activity of three CMP groups increased significantly （P 〈 0.01 ）,and the level of MDA decreased significantly （P 〈0.01）compared with CY group.As for CAT activity of heart,the value in low-dose CMP group had no significant change （P 〉0.05）,while in middle and high-dose groups had significant （P 〈0.05 ）and extremely significant（P 〈 0.01 ）increase respectively.Except that the hepatic GSH-Px activity increased significantly （P 〈0.05 ）in low-dose CMP group,the rest values of 〈br〉 GSH-Px activities in all CMP groups increased extremely significantly （P 〈0.01 ）.The results indicated that CMP could effectively improve the antioxidant function of mice and had the potential to be a good resource of new antioxidant drugs.