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中文摘要：
采用LPS人工复制仔猪发热模型,攻毒5h后按要求给于清开灵。监测各时间段的体温以及在0,5,30,72h各时段采血用ELISA法检测PGE2、cAMP、α-MSH和AVP的含量。结果显示：在注射LPS时,各组PGE2、cAMP、AVP、α-MSH的含量无显著性差异（P〉0.05）;在注射LPS 5h后,与空白组相比,模型组PGE2、cAMP、AVP和α-MSH的含量升高;在30h时,与模型组相比,清开灵各组PGE2、cAMP含量降低,AVP含量升高,且差异显著（P〈0.05）;在72h时,清开灵各组PGE2、cAMP、AVP和α-MSH的含量与空白组比较差异不显著（P〉0.05）。体温与上述相关因子存在显著相关性。结果表明：清开灵有明显的解热作用,其机制可能是通过诸多调节因子共同调节的作用。
英文摘要：
Fever model was reproduced with LPS to study the effect of regulatory factor of Qingkailing （QKL） on LPS-incluced fever in piglets. 5 h later after LPS, each group was given drugs according to requirement. The body temperature was measured at different periods and the con tents of PGE2,cAMP,α-MSH,AVP were measured in serum at 0,5,30 and 72 h by ELISA. The results showed that the contents of PGE2,cAMP, AVP and α-MSH of each group had no signifi- cant difference （P〉0.05） before LPS. After 5 h of injecting LPS,compared with the blank group, the contents of PGE2,cAMP,AVP and α-MSH were increased in model group. At 30 h,compared with the model group, the contents of PGE2 and cAMP were significantly reduced（P〈0.05）,but the contents of AVP were significantly increased （P〈0.05） in other groups. At 72 h,compared with the blank group,there were no significant difference of PGE2,cAMP,AVP,and α-MSH（P〉 0.05） in other groups. There was a significant correlation between the body temperature and the contents of PGE2,cAMP,AVP and α-MSH. This suggests that QKL have significantly antipyretic effect. The mechanism may be related to the regulation of various regulatory factors.
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