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中文摘要：
为了从氰基丙烯酸酯类衍生物中寻找新的活性化合物,采用活性亚结构拼接方法,设计并合成了17个未见文献报道的新型含氟甲基吡唑结构的氰基丙烯酸酯类化合物.利用1H NMR、13C NMR和元素分析对所制备的化合物的结构进行了表征.此外,利用MS证实了化合物7b、7f、7j和7o的结构.初步的生物活性测试结果显示,部分目标化合物表现出明显的抗肿瘤活性.
英文摘要：
In order to find novel cyanoacrylate lead compounds, 17 new cyanoacrylate compounds bearing fluoride methyl pyrazole moiety were synthesized by the method of active substructure combination. They were structurally confirmed by 1H NMR, 13 C NMR and elemental analysis. The structures of compounds 7b, 7f, 7j and 7o were also tested through MS technique. Preliminary bioassay data showed that some of the target compounds displayed important anti-tumor activities.
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同项目期刊论文
Design, Synthesis and Bioactivities of Novel Dichloro-Allyloxy-Phenol-Containing Pyrazole Oxime Deri
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