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VEGF和ANG-1、2在米非司酮药物流产后出血绒毛蜕膜组织中的表达及意义

ISSN号：1008-0104
期刊名称：《黑龙江医药科学》
时间：0
分类：R714.2[医药卫生—妇产科学;医药卫生—临床医学]
作者机构：[1]佳木斯大学附属第一医院妇产科,黑龙江佳木斯154003, [2]佳木斯市中心医院妇产科,黑龙江佳木斯154002
相关基金：黑龙江省卫生厅科研课题,编号：2011-390.

关键词：血管内皮生长因子, 血管生成素1、2, 药物流产, 异常出血, vascular endothelial growth factor, VEGF, angiogenin, Ang , medical abortion, abnormal bleeding

中文摘要：

目的：研究血管生成素1、2 （Ang-1、2）和血管内皮生长因子（VEGF）在药物流产后异常出血子宫内膜组织的表达,研究药物流产后异常子宫出血的病因,为预防和治疗药物流产术后异常出血的不良反应提供有力的理论依据.方法：应用SABC免疫组织化学法对正常早孕绒毛、蜕膜标本（20例）,药物流产后子宫异常流血患者残留绒毛、蜕膜标本（30例）,药物流产完全的绒毛组织标本（30例）中ANG-1、2,Vegf的表达进行研究.结果：①Vegf蛋白在正常早孕绒毛组织中未检测到,不完全药物流产组绒毛组织中VEGF表达显著高于正常早孕妇女绒毛组织及完全组药物流产绒毛组织,差异比较有显著性（P＜0.05,P＜0.01）.②ANG-1、2蛋白在不完全药物流产组绒毛组织的表达中显著高于完全组药物流产绒毛组织和正常早孕妇女绒毛组织,差异比较有显著性（P＜0.01,P＜0.05）,Ang-1/Ang-2比例对照三组没有显著改变.结论：①药物流产后造成子宫出血时间延长以及出血量多的重要原因是绒毛及蜕膜组织残留.②药物流产绒毛蜕膜组织中VEGF/ANG-1、2的表达增强,有力证明异常出血与其促血管生成,提供残留的蜕膜及绒毛组织血运,与其生长有密切相关性.

英文摘要：

Objective.Our study is to investigate the expression of vascular endothelial growth（VEGF） and angiogenin -1,2 （Ang-1,2） in endometrium of women with abnormal bleeding after medical abortion; to analyze the main reason of abnormal bleeding~ and to provide a theoretical basis for fight against the deputy reaction of medical abortion. Methods：The immunocytochemical method was used to detect the expression of angiogenin-1,2 and Vascular Endothelia Growth Factor in early pregnant chorionic villi and deciduas from 20 cases of requesting termination of pregnancy by curettage, 30 cases of incomplete medical abortion ,and 30 cases of compiete medical abortion. Results： ①the VEGF protein have been detected in early pregnant chorionic villi; VEGF in early pregnant chorionic villi and deciduas in incomplete abortion group were significantly higher than those in normal early pregnant and the complete abortion group （P 〈 0. 05,P 〈 0. 01）②Ang-1,2 expression level in incomplete abortion group was significantly higher than those in the complete abortion group and curettage group （P 〈 0.01,P 〈0. 05）; the rate of Ang-1/Ang-2 was hardly varied around three groups. Conclusion：The remains of villus were the main reasons of abnormal bleeding after medical abortion. The hyper expression of VEGF and Ang- 1,2 in endometrium may play an important role in abnormal bleeding after medical abortion.

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