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中文摘要：
[目的]评价CXCR4基因在食管鳞癌术后早期复发转移患者中的表达。[方法]选择43例术后早期复发转移食管鳞癌标本、46例术后1年内未发生复发转移食管鳞癌标本和17例正常食管组织标本，应用RT-PCR和WestemBlot方法检测标本中CXCR4基因mRNA和蛋白的表达情况。[结果]与术后1年内未发生复发转移食管鳞癌组织和正常食管组织相比．术后早期复发转移食管鳞癌标本CXCR4基因的mRNA和蛋白的表达存在明显上调，差异有统计学意义（P〈0．05）。[结论]在食管鳞癌组织中CXCR4基因表达的改变可能与肿瘤复发转移有关。
英文摘要：
[Purpose j To investigate the expression of CXCR4 gene in esophageal squamous cell patients with early postoperative recurrence and metastasis. [Methodsl Forty-three tissue samples with early postoperative recurrence and metastasis of esophageal squamous cell carcinoma, 46 tis- sue samples with postoperative esophageal squamous cell carcinoma without recurrence or metas- tasis within one year, and 17 samples with normal esophageal tissue were enrolled, mRNA and protein of CXCR4 expressions were detected by RT-PCR and western blot. [Results] Compared to postoperative esophageal squamons cell eareinoma without reeuta~nce within one year and nor- mal esophageal tissues, CXCR4 mRNA and protein expression in case with early postoperative recurrence and metastasis of esophageal squamous cell carcinoma tissue samples were up-regulat- ed with statistically different （P〈0.05）. [Conclusions] CXCR4 in esophageal squamous cell carci- noma gene expression changes may be related to tumor recurrence and metastasis.
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