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锌对辣椒素激活的神经元磷酸化胞外信号调节激酶表达的影响

ISSN号：1006-2947
期刊名称：《解剖科学进展》
时间：0
分类：R735.37[医药卫生—肿瘤;医药卫生—临床医学]
作者机构：[1]四川省简阳市人民医院普外科,四川简阳641400
相关基金：四川省资阳市科技局立项课题,（编号：2013024）

关键词：低位直肠癌, 直肠癌根治术, 盆腔自主神经, 排尿功能, 性功能, Low rectal cancer, Radical proctectomy for rectal cancer, Pelvic autonomic nerve, Urinary function, Sexual function

中文摘要：

目的：探讨男性低位直肠癌根治术中保留盆腔自主神经对排尿功能及性功能的保护作用。方法：选择符合标准的患者80例，随机分为观察组和对照组各40例。对照组采用传统直肠癌根治术，观察组采用保留盆腔自主神经直肠癌根治术，观察比较两组患者手术基本情况，以及手术后6个月排尿功能及性功能。结果：观察组患者手术时间较对照组延长，差异存在统计学意义（ P＜0．05）；但是观察组患者没有增加术中出血量和肿瘤下切缘，没有降低淋巴结清扫个数，与对照组相似差异无统计学意义（ P＞0．05）。术后6个月，观察组排尿功能、勃起功能及射精功能均明显优于对照组，差异有统计学意义（ P＜0．05）。结论：男性低位直肠癌根治术保留盆腔自主神经没有增加手术创伤和降低淋巴结清扫率，而且对患者排尿及性功能具有积极的保护作用，值得临床推广应用。

英文摘要：

Objective：To investigate the protective effect of pelvic autonomic nerve preservation in radi-cal proctectomy for low rectal cancer in male patients on the urinary and sexual functions .Method：Eighty el-igible patients were selected and randomly divided into observation group and control group , with 40 patients in each group .The control group used traditional radical proctectomy for rectal cancer , while the observation group used radical proctectomy for rectal cancer with pelvic autonomic nerves preserved , and the general conditions when operation and the urinary and sexual functions at 6 months after the surgery were observed and compared between the patients of the two groups .Result：The operative time of the patients in the obser-vation group was longer than that of the control group , and the difference was statistically significant （ P〈0. 05）;but the patients of the observation group , the intra-operative blood loss and distal margin were not in-creased and the number of lymph nodes cleared didn＆#39;t decrease;the numbers were similar with those of the patients of the control group, and the differences were statistically insignificant （P〉0.05）.At 6 months after the surgeries , the urinary function , erectile function and ejaculatory function of the patients of the observation group were all significantly better than those of the control group （ P〈0.05） .Conclusion：Radical proctecto-my for low rectal cancer with pelvic autonomic nerves preserved in male patients doesn＆#39;t increase operation wound or decrease lymph node clearance rate , has protective effects on the urinary and sexual functions in the patients , and consequently is worthy of clinical application .

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