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中文摘要：
目的：探讨ABO-HDN早期诊断指标的特征及临床价值。方法：分析280例ABO溶血病筛查的新生儿三项诊断试验结果与初检时间、同期的血常规以及血清胆红素检测指标。结果：99例诊断为ABO-HDN阳性,其中A型54例,B型45例,血型分布差异无统计学意义（P〉0.05）;A型、B型HDN阳性组与HDN阴性组Hb水平差异有统计学意义（P〈0.01）,但99例HDN阳性组不同血型、不同初检日期Hb水平差异无统计学意义（P〉0.05）。不同初检日期的HDN阳性率差异无统计学意义（P〉0.05）,若只分析病理性黄疸患儿,不同初检日期的HDN阳性率差异亦无统计学意义（P〉0.05）;所有HDN阳性诊断模式中的初检日期无明显差异（P〉0.05）;直抗、游离试验结果与初检天数差异无统计学意义（P〉0.05）;所有ABO-HDN阳性患儿出现病理性黄疸占45.45%（45/99）,HDN阳性与阴性的间胆与总胆比值差异有统计学意义（P〈0.05）;而总胆红素、直接胆红素与间接胆红素未见明显差异（P〉0.05）。若只分析病理性黄疸患儿,HDN阳性与HDN阴性的各胆红素指标均未见明显差异（P〉0.05）。结论：轻中度的贫血以及间胆与总胆比值是早期ABO-HDN诊断的辅助指标,且大多贫血不呈进行性加重,临床上不应以出现病理性黄疸后再考虑筛查ABO-HDN。抗体释放试验是最灵敏的、也是疾病进展后最重要的确诊指标。
英文摘要：
Objective：To investigate the characters and clinical significance of early diagnostic markers in ABO incompatible HDN. Methods：Some laboratory data such as blood routine tests and serum bilirubin and the first diagnostic date in 280 cases neonates needed to detect for ABO-HDN were collected and analyzed. Results：Ninety-nine cases were diagnosed as ABO-HDN,including 54 case of type A（54.5%）,45 case of type B（45.5%）,and the distribution of blood were not significantly different between the two types（P〈0.05）.The levels of plasma hemoglobulin in type A or type B ABO-HDN were significantly different compared with none-HDN（P〈0.01）,but the levels of hemoglobulin in all ABO-HDN were not significantly different in different blood type as well as different first diagnostic date（P〈0.05）.The positive rates of ABO-HDN as well as that of ABO-HDN with developed pathological jaundice were not significantly different in different first diagnostic date（P〈0.05）.The distribution of the first diagnostic date in all positive diagnostic models of ABO-HDN and the positive rates of direct antiglobulin test and that of serum free hemolytic antibody test were not significant different（P〈0.05）.The percent of neonates developed pathological jaundice in all ABO-HDN was 45.45%（45/99）,the ratio of indirect bilirubin to total bilirubin was significantly different between ABO-HDN and non-HDN neonates（P〉0.05）,but the levels of total bilirubin,direct bilirubin and indirect bilirubin were not significantly different between ABO-HDN and non-HDN neonates（P〈0.05）as well as between ABO-HDN and non-HDN neonates developed pathological jaundice. Conclusion：Mild or medium anemia can be the early auxiliary index for ABO HDN and progressive exertional anemia is seldom.Clinical decision to screen ABO-HDN by laboratory investigation should not be delayed until neonates developed pathological jaundice.Antibody elution test is the most sensitive and important diagnostic markers during the progression o
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