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中文摘要：
目的：探讨他莫昔芬的不良反应特点及其临床表现,为临床监测其不良反应并避免严重不良后果提供参考。方法：通过检索＂中国期刊全文数据库＂、＂万方数据库＂等,收集2000–2010年国内医药学期刊发表的他莫昔芬的不良反应文献报道,分别从患者性别与年龄的分布、用药情况、ADR发生时间、ADR累及器官或系统及临床表现等方面进行整理分析。结果：共检索到47篇相关文献,涉及212例病例,51～60岁患者服用他莫昔芬剂量超过20 mg.d-1时不良反应发生率最高。他莫昔芬引起的子宫内膜损害最为多见,其次为肝、眼等器官损害,其他不良反应散在发生。结论：在临床应用过程中,应关注他莫昔芬引起的不良反应,可以通过对患者用药过程进行监护等措施确保患者用药安全。
英文摘要：
Objective： To investigate the clinical manifestations and characteristics of ADRs induced by tamoxifen,and provide reference for monitoring and avoiding serious ADRs.Methods： The literatures between 2000 and 2010 were retrieved from＂ Chinese Academic Journal＂ and＂ Wafang Database＂,the data in respect of distribution of gender and age,the situation of medication,occurrence time of ADR,organs or systems involved in ADRs and clinical manifestations were analyzed.Results： Forty seven articles were collected,and 212 cases were involved in.The occurrence of ADRs in the patients whose ages were between 51 and 60 years and whose doses were over 20 mg.d-1 was high.The endometrial damages induced by tamoxifen in postmenopausal women were the most common ADR,followed by the damage of the liver and eye.Conclusion： Treatment with tamoxifen should be monitored closely.Stop taking tamoxifen at once if the serious ADRs occurred.Symptomatic treatments should be given to avoid serious adverse events.Monitoring the process of medication can be used to ensure medication safety.
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