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中文摘要：
目的：研究谷胱甘肽-S-转移酶P1（glutathione S-transferases P1，GSTP1）基因第105位点的遗传多态性与恶性肿瘤患者对铂类药物化疗敏感性的关系。方法：收集50例经病理确诊且CT扫描证实有可测量病灶并接受以顺铂为主的化疗的恶性肿瘤患者，于化疗前抽取外周静脉血，采用基因测序的方法对GSTP1基因第105位点的单核苷酸多态性（single nueleotide polymor—phisms，SNPs）进行检测，观察这些患者经2—4个周期化疗后的疗效，分析各基因分型与铂类药物化疗敏感性的关系。结果：GSTP1基因第105位点基因型的分布与病种无关（P〉0．05）。携带GSTP1基因第105位密码子的Ile／Ile、Ile／Yal和Val／Va13种基因型的患者对铂类药物化疗有效率分别为20．0％、36．4％和87．5％，携带纯合突变型Val／Val基因分型的患者的敏感性明显高于携带另外2种基因分型的患者（P〈0．05）。结论：GSTP1基因单核苷酸多态性可能与铂类药物化疗敏感性相关。
英文摘要：
Objective： To investigate the relationship between genetic polymorphism in 105 codons of the glutathione S-transferase P1 （ GSTP1 ） gene and patient sensitivity to platinum-based chemotherapy. Method： A total of 50 cancer patients were enrolled in our study, which were confirmed by pathologic diagnosis and CT scanning to have measurable lesions and then subjected to platinum-based chemotherapy. Peripheral blood was obtained before the therapy, and direct sequencing was performed to detect single nucleotide polymorphisms （ SNPs ） in the 105 codons of GSTP1 in peripheral blood. The clinical responses of these patients after 2 to 4 cycles of chemotherapy were observed. The relationship between SNPs of the GSTP1 gene and clinical responses was analyzed. Results： No correlation was found between the distribution of GSTPI genotypes and different cancers （ P 〉 0.05 ）. The response rates to chemotherapy in patients with the Ile/Ile, Ile/Val, and Val/Val genotypes in the 105 GSTP1 codons were 20.0%, 36.4% and 87.5%, respectively. The response rate was higher in the patients with the homozygous Val/Val mutant genotype than in those with the Ile/Ile or Ile/Val genotypes （ P 〈 0.05 ）. Conclusion： Single nucleotide polymorphisms of the GSTP1 gene may be associated with sensitivity to platinum-based chemotherapy.
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