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中文摘要：
1例51岁女性患者因甲状腺功能亢进症服用甲巯咪唑5mg，1次／d，10d后出现皮肤瘙痒、恶心、呕吐、大便呈灰白色，第15天停用甲巯咪唑。实验室检查示丙氨酸转氨酶（ALT）184U／L，天冬氨酸转氨酶（AST）115U／L，总胆红素（TBil）41．6μmol／L，直接胆红素（DBil）28．6μmol／L，碱性磷酸酶（ALP）342U／L。考虑为药物所致胆汁淤积型肝损伤。遂静脉滴注脱氧核苷酸钠注射液150mg，1次／d和注射用复合辅酶400U，2次／d。保肝治疗第7天ALT150U／L，AST67U／L，TBil28．7μmol／L，DBIL19．1μmol／L；第13天A坍93U／L，AST57U／L；第28天ALT62U／L，AST45U／L。TBil11．1μmol／L，DBil5．8μmol／L。
英文摘要：
A 51-year-old woman with hyperthyroidism was given thiamazole 5 mg once daily. Ten days later, the patient presented itchiness, nausea, vomiting, and gray excrements. On day 15, the thiamazole was withdrawn. Laboratory examination revealed the following levels： alanine aminotransferase （ALT） 184 U/L, aspartate aminotransferase （AST） 115 U/L, total biliruhin（TBil） 41.6 μmol/L, and direct bilirubin （DBil） 28.6 μmol/L. The patient was considered as cholestatic liver injury. She was given an IV infusion of sodium deoxyribonucleotide injection 150 mg once daily and coenzyme complex for injection 400 U twice daily. On day 7 of liver-protective treatment, laboratory examination showed the following levels： ALT 150 U/L,AST 67 U/L, TBil 28.7 μmol/L, and DBil 19.1 μmol/L. On day 13, the levels of ALT and AST were 93 U/L,and 57 U/L, respectively. On day 28, the levels of ALT, AST,TBil and DBil were 62 U/L, 45 U/L, 11.1 μmoL/L, and 5.8 μmol/L, respectively.
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