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中文摘要：
食物过敏是一个全球性公共卫生问题,检测和评价食物过敏原的致敏性也日益受到重视.食物过敏原致敏性的评估方法可分为体内法、体外法和生物信息学比对法.体内法主要包括双盲安慰剂对照的食物激发实验、皮肤实验和动物模型.体外法包括过敏原吸附抑制实验、免疫印迹法、酶联免疫吸附实验和组胺释放实验等.生物信息学比对法主要用于转基因食物中过敏原的致敏性评价.虽然评价食物过敏原致敏性的方法众多,但是目前还没有一种独立的方法能够完全有效地评价食物过敏原的致敏性.因此,应尽快建立快速、高效、精准的评价方法.
英文摘要：
Food allergy is a global public health problem and allergenicity assessment of food allergens has drawn increasing attention.There are three ways to assess the allergenicity of food allergens,including in vivo,in vitro and bioinformatic methods.The currently available in vivo approaches include double-blind placebo-controlled food challenges,skin testing and animal model.The in vitro methods include allergosorbent test inhibition,immunoblotting,enzyme linked immunosorbent assay,histamine-releasing test,and so on.Bioinformatic method is mainly used to assess the allergenicity of transgenic crops.Although many methods are available for allergenicity assessment of food allergens,no single method can assess the allergenicity of food allergens efficiently.Therefore,it is urgent to develop a way for the fast,efficient and accurate assessment of food allergenicity.
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