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Suspended moxibustion relieves chronic visceral hyperalgesia and decreases hypothalamic corticotropin-releasing hormone levels

ISSN号：1007-9327
期刊名称：《世界胃肠病学杂志：英文版》
时间：0
分类：Q426[生物学—神经生物学;生物学—生理学] S859.799.9[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医]
作者机构：[1]Department of Mechanicsand Engineering Science, Fudan University, Shanghai 200433,China, [2]Key Laboratory of Acupuncture-Moxibustion and Immunological Effects, Shanghai Universityof Traditional Chinese Medicine, Shanghai 201203, China, [3]Shanghai Research Center of Acupunctureand Meridians, Shanghai 200433, China
相关基金：Supported by The National Basic Research Program of China （973 program）, No. 2009CB522900; the Shanghai Leading Academic Discipline Project, No. S30304; and Shanghai Foundation for Development of Science and Technology, China, No. 08DZ1973000

作者： En-Hua Zhou[1,2], Xiao-Mei Wang[2], Guang-Hong Ding[1,3], Huan-Gan Wu[2], Li Qi[2], Hui-Rong Liu[2], Shu-Jing Zhang[1]

关键词：促肾上腺皮质激素, 激素水平, 痛觉过敏, 下丘脑, 内脏, 慢性, MRNA水平, 大鼠模型, Chronic visceral hypersensitivity, Corticotro-pin-releasing hormone, Irritable bowel syndrome, Rat, Suspended moxibustion

中文摘要：

瞄准：为了在直肠的感觉阀值上评估推迟的艾灸(SM ) 的效果并且分析，可能的机制在老鼠在 SM 包含了长期的内脏的超敏性(CVH ) 的处理。方法：SM 每天为 7 d 予 37-d-old CVH 老鼠被以一次。二 acupoints (ST25 和 ST37，双边) 同时与 SM 被对待。每个处理持续了 30 min。与 SM 经历处理的老鼠不是 anesthetized。未经治疗的 CVH 老鼠和正常老鼠被用作控制。腹的退却反射是在七治疗以后的坚定的 30-90 min。hypothalamic 释放促肾皮素的荷尔蒙(CRH ) mRNA 水平用即时量的反向的抄写聚合酶链反应被测量。结果：我们发现那个 SM 处理显著地减少了内脏的敏感到在这个老鼠模型的 colorectal 膨胀。在对待的动物， SM 也减少了控制层次的相对 hypothalamic CRH mRNA 表示水平。结论：更低的 hypothalamic CRH 层次可以调停在这只老鼠的 SM 的有益的效果急躁的肠症候群模型。

英文摘要：

AIM： To evaluate the effect of suspended moxibustion （SM） on rectal sensory thresholds and to analyze the possible mechanisms involved in SM treatment of chronic visceral hypersensitivity （CVH） in rats. METHODS： SM was administered once daily to 37-d- old CVH rats for 7 d. The two pairs of acupoints （ST25 and ST37, bilateral） were simultaneously treated withSM. Each treatment lasted for 30 min. Rats undergoing treatment with SM were not anesthetized. Untreated CVH rats and normal rats were used as controls. The abdominal withdrawal reflex was determined 30-90 min after the seven treatments. The hypothalamic cortico- tropin-releasing hormone （CRH） mRNA level was measured using real-time quantitative reverse transcriptionpolymerase chain reaction. RESULTS： We found that SM treatment significantly decreased visceral sensitivity to colorectal distention in this rat model. In treated animals, SM also decreased the relative hypothalamic CRH mRNA expression level to control levels. CONCLUSION： Lower hypothalamic CRH levels may mediate the beneficial effects of SM in this rat irritable bowel syndrome model.

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