中文摘要：

瞄准：与 Crohns 疾病(CD ) 在老鼠在结肠的上皮的房间 apoptosis 的下面规定和紧密的连接的修理上调查艾灸的效果。方法：六十只男 Sprague-Dawley 老鼠随机被划分成正常控制(NC ) 组，一个模型控制(MC ) 组，一个划分植物的艾灸(HPM ) 组，一个温和温暖的艾灸(MWM ) 组和 salicylazosulphapyridine (SASP ) 组，带着在每个组的 12 只老鼠。CD 模型老鼠与 trinitrobenzene 磺基酸被对待导致肠的发炎。在 HPM 和 MWM 组的老鼠在 Tianshu (ST25 ) 和为 14 d 从前每日的 Qihai (CV6 ) acupoints 被对待，并且 SASP 组是为 14 d 两次每日的喂的 SASP。没有另外的处理被给 MC 和 NC 组。结肠的上皮的微观结构在一台传播电子显微镜下面被观察， transepithelial 电阻用电线走火被测量当前的、结肠的上皮的房间 apoptosis 被终端 deoxynucleotidyl 决定 occludin 的 调停transferase 的 dUTP-biotin 刻痕结束标记试金，和表示，在结肠的上皮的连接的 claudin-1 和 zonula occludens-l ( ZO-1 )被西方的弄污并且 immunofluorescence 染色决定。结果：与 MC 组相比，结肠的上皮的障碍的微观结构显著地在同时，与 HPM， MWM 或 SASP 对待的老鼠被改进当前的流动显著地被减少，与 168.20 的价值

英文摘要：

AIM： To investigate the effects of moxibustion on down-regulation of the colonic epithelial cell apoptosis and repair of the tight junctions in rats with Crohn’s disease （CD）. METHODS： Sixty male Sprague-Dawley rats were randomly divided into a normal control （NC） group, a model control （MC） group, an herbs-partitioned moxibustion （HPM） group, a mild-warm moxibustion （MWM） group and a salicylazosulphapyridine （SASP） group, with 12 rats in each group. The CD model rats were treated with trinitrobenzene sulphonic acid to induce intestinal inflammation. The rats in the HPM and MWM groups were treated at the Tianshu （ST25） and Qihai （CV6） acupoints once daily for 14 d, and the SASP group was fed SASP twice daily for 14 d. No additional treatment was given to the MC and NC groups. Themicrostructure of the colonic epithelium was observed under a transmission electron microscope, the transepithelial resistance was measured using a shortcircuit current, colonic epithelial cell apoptosis was determined by terminal deoxynucleotidyl transferasemediated dUTP-biotin nick end labelling assay, and the expression of occludin, claudin-1 and zonula occludens-l （ZO-1） in the colonic epithelial junction was determined by Western blotting and immunofluorescence staining. RESULTS： Compared with the MC group, the microstructure of the colonic epithelial barrier was signifi-cantly improved in rats treated with HPM, MWM or SASP, meanwhile, the current flow was reduced signifi-cantly, with values of 168.20 ± 6.14 vs 99.70 ± 3.13, 99.10 ± 4.28 and 120.30 ± 3.65 mA, respectively （P = 0.001）. However, the HPM and MWM groups had higher current flow rates than the SASP group （99.70 ± 3.13, 99.10 ± 4.28 vs 120.30 ± 3.65 mA, P = 0.001）. The number of the apoptotic colonic epithelial cells in HPM, MWM and SASP groups was largely reduced （61.5 ± 16.91 vs 15.5 ± 8.89, 14.8 ± 6.27 and 24.7 ± 9.68, respectively （P = 0.001）; and the expression of occlu- din, claudin-1 and ZO-1 in the