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艾灸温度影响因素及与疗效关系研究进展

ISSN号：1674-1749
期刊名称：环球中医药
时间：2013.4.6
页码：309-313
分类：R2-03[医药卫生—中医学]
作者机构：[1]Shanghai Research Institute ofAcupuncture and Meridian,Shanghai 200030, China, [2]Changhai Hospital of Shanghai,the Second Military MedicalUniversity, Shanghai 200433,China
相关基金：supported by National Natural Science Foundation of China（No.81173331）; Scientific Research Budget Project of Shanghai Municipal Education Commission（No.2011JW46）; Science and Education Department Project for Youth,Shanghai Municipality Health Bureau（No.20124Y004）
相关项目：基于代谢组学方法研究艾灸生成物及其效应与安全性

关键词：大肠炎, ULCERATIVE, 艾灸治疗, 间接艾灸, NF-kappa, B, PPAR, gamma, 老鼠, R2-03, Colitis,Ulcerative Moxibustion Therapy Indirect Moxibustion NF-kappa B PPAR gamma Rats

中文摘要：

通过观察结肠的 mucosal 为 ulcerative 大肠炎(UC ) 探索划分植物的艾灸的机制组织病理学说的变化和原子因素 kappaB (NF-B ) 和 peroxisome 的表示 UC 老鼠的激活 proliferators 的受体(PPAR ) mRNA。

英文摘要：

Objective： To explore the mechanism of herb-partitioned moxibustion for ulcerative colitis（UC） through observing the colonic mucosal histopathological changes and the expression of nuclear factor kappaB（NF-kB） and peroxisome proliferators-activated receptor γ（PPARγ） mRNA of UC rats. Methods： Male SD rats were randomly divided into a normal group and a model group. UC model was established by general immunological plus local irritation method. After model identification, rats in the model group were randomly divided into a model group, a herb-partitioned moxibustion（HPM） group and a Western medicine（Salicylazosulfapyridine, SASP） group. Rats in the HPM group received treatment at bilateral Tianshu（ST 25） and Dachangshu（BL 25）, two cones for each point, once a day for 7 d. SASP group rats were gavaged with SASP. The pathological scores were evaluated according to hematoxylin-eosin（HE） staining of colonic tissues. We used light microscopy to observe degree of colonic mucosal damage and the quantitative polymerase chain reaction（QPCR） to detect the expression of NF-κBp65 and PPARγ in colorectal mucosa. Results： Compared with the normal group, histopathological scores were significantly higher in the model group（P〈0.05）; compared with the model group, the scores were decreased significantly in the HPM group and the SASP group. Compared with the normal group, NF-κBp65 mRNA expression was increased with statistical significance in the model group（P〈0.05）; compared with the model group, NF-κBp65 mRNA expressions were decreased significantly in the HPM group and the SASP group. Compared with the normal group, PPARγ mRNA expression was increased significantly in the model group（P〈0.05）; compared with the model group, PPARγ mRNA expressions were decreased significantly in the HPM group and the SASP group. Conclusion： HPM could improve the mucosa damage of UC rats, which is possibly through down-regulating NF-κBp65 to achieve anti-inflammatory effect. Whe

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