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Comparison of Electroacupuncture and Moxibustion on Brain- Gut Function in Patients with Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized Controlled Trial
  • ISSN号:1673-842X
  • 期刊名称:《辽宁中医药大学学报》
  • 时间:0
  • 分类:Q426[生物学—神经生物学;生物学—生理学] S852.2[农业科学—基础兽医学;农业科学—兽医学;农业科学—畜牧兽医]
  • 作者机构:[1]Yueyang Clinical School of Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai (201203), China, [2]Medical Imaging Department, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province (321000), China, [3]Department of Acupuncture and Moxibustion, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province (321000), China, [4]Department of Digestive System, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province (321000), China, [5]Radiology Department, Huashan Hospital, Fudan University, Shanghai (200040), China, [6]Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis (46202), USA, [7]Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai (200437), China
  • 相关基金:Supported by the National Natural Science Foundation of China (No. 30973784), Major State Basic Research Development Program of China (973 Program, No. 2009CB522900), and Shanghai Leading Talent Project of Traditional Chinese Medicine (No. ZYSNXD-RC-LJRC) Acknowledgement We are grateful to ZHANG Zhong-wei from Ruijin Hospital, Shanghai Jiaotong University School of Medicine for technical assistance of fMRI, PANG Hui-fang from Basic Medical School of Shanghai University of Traditional Chinese Medicine for guidance on the pathology, and JU Li-hua from University of Shanghai for Science and Technology School of Medical Instrument and Food Engnieering and WU Zhong-hua from the Experiment Center of Science and Technology of Shanghai University of Traditional Chinese Medicine for providing laboratory instruments and technical guidance.
中文摘要:

在病人上把 electroacupuncture (EA ) 和艾灸治疗的效果与腹泻占优势的急躁的肠症候群作比较的目的(把钓饵轻轻放进水里) 。60 全部的方法 A 把钓饵轻轻放进水里病人们随机被分配到 EA 组(30 个盒子) 和艾灸组(30 个盒子) 。在治疗前后,胃肠的症状和心理症状被视觉类似物规模,布里斯托尔凳子形式规模,哈密尔顿焦虑等级规模(HAMA ) ,和评估规模(HAMD ) 的哈密尔顿消沉获得;5-hydroxytryptamine (5-HT ) 的表情, 5-HT 3 受体(5-HT3R ) ,和在 S 字形的 mucosal 织物的 5-HT 4 受体(5-HT4R ) 被染色的 immunohistochemical 测量。另外,前面的 cingulate 外皮(ACC ) 的功能的大脑区域上的效果,海岛的外皮(IC ) 和前额的外皮(陆军) 被功能的磁性的回声成像观察。与以前相比结果治疗, EA 和艾灸组腹的疼痛并且在治疗以后的腹的膨胀地报导了重要改进(P < 0.01 或 P < 0.05 ) 。艾灸组比 EA 组在澄清紧急情况,澄清频率,和凳子特征报导了更大的改进(P < 0.01 ) 。HAMA 和 HAMD 分数显著地比在 EA 组在艾灸组被减少(P < 0.01 ) 。signifificantly 表明的两个组在处理以后在结肠的 mucosa 减少了 5-HT, 5-HT3R 和 5-HT4R 的表情(P < 0.01 ) ,与在艾灸组的 5-HT 的更大的减小(P < 0.05 ) 。最后,减少了激活的 voxel 价值在治疗以后与 150 mL colorectal 扩张在刺激下面在艾灸组在左 IC ,正确 IC 和病人的陆军大脑区域被观察( P < 0.05 或 P < 0.01 ),当在 EA 组仅仅陆军区域表明了减小时( P < 0.05 )。结论艾灸能 signifificantly 改进症状把钓饵轻轻放进水里,建议那艾灸可以比 EA 为是更有效的治疗把钓饵轻轻放进水里病人。

英文摘要:

Objective: To compare the effects of electroacupuncture (EA) and moxibustion therapies on patients with diarrhea-predominant irritable bowel syndrome (D-IBS). Methods: A total of 60 D-IBS patients were randomly allocated to the EA group (30 cases) and moxibustion group (30 cases). Before and after treatment, the gastrointestinal symptoms and psychological symptoms were scored by Visual Analogue Scale, Bristol Stool Form Scale, Hamilton Anxiety Rating Scale (HAMA), and Hamilton Depression Rating Scale (HAMD); the expressions of 5-hydroxytryptamine (5-HT), 5-HT3 receptor (5-HT3R), and 5-HT4 receptor (5-HT4R) in the sigmoid mucosal tissue were measured by immunohistochemical staining. Additionally, the effects on the functional brain areas of the anterior cingulate cortex (ACC), insular cortex (IC) and prefrontal cortex (PFC) were observed by functional magnetic resonance imaging. Results: Compared with before treatment, both EA and moxibustion groups reported significant improvements in abdominal pain and abdominal bloating after treatment (P〈0.01 or P〈0.05). The moxibustion group reported greater improvements in defecation emergency, defecation frequency, and stool feature than the EA group (P〈0.01). Both HAMA and HAMD scores were significantly decreased in the moxibustion group than in the EA group (P〈0.01). Both groups demonstrated significantly reduced expressions of 5-HT, 5-HT3R and 5-HT4R in the colonic mucosa after treatment (P〈0.01), with a greater reduction of 5-HT in the moxibustion group (P〈0.05). Finally, decreased activated voxel values were observed in the left IC, right IC and PFC brain regions of patients in the moxibustion group under stimulation with 150 mL colorectal distension after treatment (P〈0.05 or P〈0.01), while in the EA group only PFC area demonstrated a reduction (P〈0.05). Conclusion: Moxibustion can significantly improve the symptoms of D-IBS, suggesting that moxibustion may be a more

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期刊信息
  • 《辽宁中医药大学学报》
  • 中国科技核心期刊
  • 主管单位:辽宁省教育厅
  • 主办单位:辽宁中医药大学
  • 主编:张立德
  • 地址:沈阳市皇姑区崇山东路79号
  • 邮编:110847
  • 邮箱:zyxb@vip.163.com
  • 电话:024-31207232
  • 国际标准刊号:ISSN:1673-842X
  • 国内统一刊号:ISSN:21-1543/R
  • 邮发代号:8-179
  • 获奖情况:
  • 中国学术期刊(光盘版)优秀期刊,中国学术期刊综合评价数据库来源期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,波兰哥白尼索引,中国中国科技核心期刊
  • 被引量:28712