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中文摘要：
目的：该文旨在为理解艾灸在温热条件下的药物作用机制提供实验事实,同时也为发明热疗法相关仪器提供导向。方法：采用药物透皮扩散试验仪,以离体鼠皮为透皮屏障,通过设置5个不同的温度,分别在每个温度下取5个不同时间点收集样品,以1,8-桉叶油素作为外标,利用气相色谱仪测定蕲艾挥发油在测定样品中的累积量。结果：实验结果表明温度对透皮吸收的影响规律更符合指数方程ln S=a＋b/T;但是以正常体温为界明显分成两段,分别进行拟合更符合规律,高温透皮吸收远远高于低温。结论：温度对透皮吸收有很大影响,在合理的温度范围内,提高温度,透过率大大增加。
英文摘要：
Objective：This paper aims to find experimental facts to help understanding the mechanism of moxibustion under warm conditions,to guided the invention of thermal therapy instruments. Methods：With the drug transdermal diffusion tester,excised rat skin were used as permeation barrier,collecting 5 samples at this 5 different time points,using gas chromatography for the determination of the cumulant of volatile oil extracted from Artemisia argyi in the determined sample with 1,8-cineole as the external standard. Results：The results show that the influence of temperatures on the transdermal absorption match the indicial equation ln S=a＋b/T,but it is clearly divided into two sections by normothermia,respectively,separately fitting conforms to the law,transdermal absorption through the skin under high temperature is much higher than under low temperature. Conclusion：The temperature has a strong effect on transdermal absorption,increasing the temperature within a reasonable range of temperatures will greatly promote through rate increases.
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