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Acupuncture-moxibustion in treating irritable bowel syndrome: How does it work?

ISSN号：1007-9327 (Print)
期刊名称：World Journal of Gastroenterology
时间：0
页码：-
分类：R574[医药卫生—消化系统;医药卫生—临床医学;医药卫生—内科学]
作者机构：Key Laboratory of Acupuncture-moxibustion and Immunology, Shanghai Research Institute of Acupuncture and Meridian, Department of Acupuncture and Moxibustion, Obstetrics and Gynecology Hospital of Fudan University, Graduate School, Shanghai University of Traditional Chinese Medicine, Research Department, Bodystat Ltd., Douglas IM99 1DQ, United Kingdom
相关基金：Supported by National Natural Science Foundation of China,No.81273843,No.81072879;National Key Basic Research Program of China,No.2009CB522900
相关项目：基于microRNA表达、TLR4/NF-κB信号通路研究隔药灸治疗克罗恩病的效应及作用机理

关键词： IRRITABLE, BOWEL, SYNDROME, Acupuncturemoxibustion, Me, Irritable bowel syndrome, Acupuncture-moxibustion, Mechanism study, Gastrointestinal motility, Visceral hypersensitivity, Brain-gut axis

中文摘要：

Irritable bowel syndrome(IBS)is a functional intestinal disease characterized by abdominal pain or discomfort and altered bowel habits.It has drawn great attention because of its high prevalence,reoccurring symptoms,and severe influence on patients’lives.Many clinical studies have demonstrated the efficacy of acupuncturemoxibustion in treating IBS.Increasing attention has been paid to research regarding the action mechanisms of acupuncture-moxibustion for IBS,and the adoption of modern techniques has achieved some progress.This article reviews the latest advances among actionmechanism studies from the perspectives of gastrointestinal motility,visceral hypersensitivity,the braingut axis,the neuroendocrine system,and the immune system.It is shown that acupuncture-moxibustion can effectively regulate the above items,and thus,this treatment should have a high efficacy in the treatment of IBS.This article also identifies existing problems in current mechanism research and raises several ideas for future studies.Further revelations regarding these action mechanisms will promote the application of acupuncture-moxibustion in treating IBS.

英文摘要：

Irritable bowel syndrome (IBS) is a functional intestinal disease characterized by abdominal pain or discomfort and altered bowel habits. It has drawn great attention because of its high prevalence, reoccurring symptoms, and severe influence on patients’ lives. Many clinical studies have demonstrated the efficacy of acupuncture-moxibustion in treating IBS. Increasing attention has been paid to research regarding the action mechanisms of acupuncture-moxibustion for IBS, and the adoption of modern techniques has achieved some progress. This article reviews the latest advances among action mechanism studies from the perspectives of gastrointestinal motility, visceral hypersensitivity, the brain-gut axis, the neuroendocrine system, and the immune system. It is shown that acupuncture-moxibustion can effectively regulate the above items, and thus, this treatment should have a high efficacy in the treatment of IBS. This article also identifies existing problems in current mechanism research and raises several ideas for future studies. Further revelations regarding these action mechanisms will promote the application of acupuncture-moxibustion in treating IBS.

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