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Factorial study of moxibustion in treatment of diarrhea-predominant irritable bowel syndrome

ISSN号：1007-93271007-9327
期刊名称：World J Gastroenterol
时间：2014.10.7
页码：13563-135672
分类：R246.1[医药卫生—针灸推拿学;医药卫生—中医临床基础;医药卫生—中医学]
作者机构：Shanghai University of Traditional Chinese Medicine, Key Laboratory of Acupuncture-Moxibustion and Immunology,Shanghai Research Institute of Acupuncture and Meridian, Traditional Chinese Medicine Hospital of Shanxi Province, Jiading Hospital of Traditional Chinese Medicine, Jiading District Central Hospital
相关基金：Supported by National Basic Research Program of China(973 Program),No.2009CB522900,2009CB522901;Shanghai Top Clinical Medical Center of Acupuncture,Moxibustion and Tuina;National Natural Sciences Foundation of China,Nos.81303031 and 81202752
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关键词： Diarrhea-predominant, IRRITABLE, BOWEL, SYNDROME, Acon, Diarrhea-predominant irritable bowel syndrome, Aconite cake-separated moxibustion, Factorial design, Moxibustion quantity, Clinical research

中文摘要：

AIM: To identify an appropriate therapeutic regimen for using aconite cake-separated moxibustion to treat diarrhea-predominant irritable bowel syndrome(D-IBS).METHODS: A factorial design was employed to examine the two factors of moxibustion frequency and number of cones. The two tested frequencies were three or six moxibustion sessions per week, and the two tested doses were one or two cones per treatment. A total of 166 D-IBS patients were randomly divided into four treatment groups, which included each combination of the examined frequencies and doses. The bilateral Tianshu acupoints(ST25) and the Qihai acupoint(RN6) were selected for aconite cake-separated moxibustion. Each patient received two courses of treatment, and each course had a duration of 2 wk. For each group, the scores on the Birmingham irritable bowel syndrome(IBS) symptom questionnaire, the IBS Quality of Life scale, the Self-Rating Depression Scale(SDS), the Self-Rating Anxiety Scale(SAS), the Hamilton Depression(HAMD) scale, and the Hamilton Anxiety(HAMA) scale were determined before treatment, after the first course of treatment, and after the second course of treatment. RESULTS: The symptom, quality of life, SDS, SAS, HAMD, and HAMA scores of the patients in all 4 aconite cake-separated moxibustion groups were significantly lower after the first and second courses of treatment than before treatment(P 【 0.001 for all). The symptom, quality of life, SDS, SAS, HAMD, and HAMA scores of the patients in all four aconite cake-separated moxibustion groups were significantly lower after the second course of treatment than after the first course of treatment(P 【 0.001 for all). Between-group comparisons after the second course of treatment revealed that the symptom scores for group 1(1 cone, 3 treatments/wk) and group 3(2 cones, 3 treatments/wk) were significantly lower than that for group 2(1 cone, 6 treatments/wk)(5.55 ± 5.05 vs 10.45 ± 6.61, P 【 0.001; 5.65 ± 4.00 vs 10.45 ± 6.61, P 【 0.001). Regarding the two levels of the two exa

英文摘要：

AIM: To identify an appropriate therapeutic regimen for using aconite cake-separated moxibustion to treat diarrhea-predominant irritable bowel syndrome (D-IBS).

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