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中文摘要：
肿瘤侵袭周边原有淋巴管以及诱导组织内新生淋巴管的形成，是肿瘤淋巴道转移的必要条件。VEGF-C和VEGF-D是特异性淋巴管生长调节因子，与淋巴管的增生和分化密切相关。二者的比值升高可能是肿瘤淋巴道转移的早期事件和潜在评估指标。本文介绍VEGF-C和VEGF-D的结构、功能、比值变化以及二者与肿瘤淋巴道转移关系的研究进展。
英文摘要：
Invasion of the surrounding original lymphatic vessel and induction of the lymphangiogenesis formation are the necessary conditions for tumor lymphatic metastasis. VEGF-C and VEGF-D are specific lymphatic growth regulators, which are closely related to the development and differentiation of lymphatic vessels. The increase of the ratio of VEGF-C to VEGF-D might be the early event and a potential evaluation index for tumorigenesis and lymphatic metastasis. This review focuses on the research progress in the structure, function and the ratio of VEGF-C to VEGF-D. The correlation between ratio of VEGF-C to VEGF-D and the tumor lymphatic metastasis is also discussed.
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