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急性胰腺炎患者人巨细胞病毒感染的血清学特征及临床特征分析

ISSN号：0253-4304
期刊名称：《广西医学》
时间：0
分类：R576[医药卫生—消化系统;医药卫生—临床医学;医药卫生—内科学]
作者机构：[1]重庆医科大学附属永川医院消化内科,重庆市402160, [2]重庆医科大学附属永川医院感染科,重庆市402160
相关基金：重庆市卫生局课题（2012-2-177）

关键词：急性胰腺炎, 人巨细胞病毒, 血清学特征, 临床特征, Acute pancreatitis, Human cytomegalovirus, Serologica1 characteristics, Clinical characteristics

中文摘要：

目的探讨急性胰腺炎（AP）患者人巨细胞病毒（HCMV）感染的血清学特征及，】盘床特征分析。方法收集456例AP患者（AP组）和280例健康普通人（对照组）的血清标本，采用电化学发光法检测所有标本中HCMV的IgG和IgM值，分析AP患者HCMV感染的血清学及临床特征。结果AP组和对照组血清HCMV．IgG阳性率分别为96．05％（438／456）和96．07％（269／280），差异无统计学意义（P〉0．05）。AP组血清HCMV—IgM阳性率为9．87％（45／456），明显高于对照组的4．64％（13／280）（P〈0．05）。HCMV—IgM阳性AP患者重度AP所占比例明显高于HCMV—IgM阴性AP患者（P〈0．05）。不同年龄段患者的HCMV—IgG阳性率比较，差异有统计学意义（P〈0．05），HCMV-IgG阳性率随年龄增加而升高。农村居住患者、女性患者及文化程度低患者HCMV—IgG阳性率增高（P〈0．05）。HCMV．IgG阳性率在不同AP病因、不同病情严重程度、不同体重指数以及是否吸烟患者中比较，差异无统计学意义（P〉0．05）。结论AP患者HCMV-IgG阳性率超过90％，与普通人群无明显差异；AP患者HCMV—IgM阳性率高于普通人群，且HCMV-IgM阳性AP患者中，重度AP比例较高；不同年龄、居住地、性别或文化程度的AP患者HCMV既往感染率有明显差异。

英文摘要：

Objective To investigate the serological and clinical characteristics of human cytomegalovirus （HCMV） infection in patients with acute pancreatitis（AP）. Methods Serum samples were collected form 456 patients with AP （AP group ） and 280 healthy individuals （ control group）. HCMV-IgG and -IgM of all the samples were determined by electrochemiluminescence immunoassay. And the serological and clinical characteristics of HCMV infection in patients with AP were analyzed. Results The HCMV-IgG positive rate of AP group and control group were 96.05 % （438/456） and 96.07 % （269/280） respectively, but there was no statistical significance between two groups （ P 〉 0.05 ）. The HCMV-IgM positive rate of AP group was 9.87% （45/456）, and was significantly higher than that of control group [ 4.64% （ 13/280）, P 〈 0.05 ]. The AP patients with positive HCMV-IgM had significantly higher proportion of severe AP compared to the AP patients with negative HCMV-IgM （P 〈 0.05 ）. There was significant difference in the HCMV-IgM positive rate among patients with different age ranges （P 〈 0.05 ） , and the HCMV-IgM positive rate increased with the increasing age. Patients lived in the rural area, female patients or patients with poor education background had higher HCMV-IgM positive rates（ P 〈 0.05 ）. There was no significant difference in the HCMV-IgM positive rate among patients with different pathogenesis of AP, patients with different severities of AP, patients with different body mass indices, or between smokers and non-smokers （ P 〉 0.05 ）. Conclusion The HCMV-IgG positive rate of patients with AP is more than 90% ,but does not differ from the rate of common individuals. The HCMV-IgM positive rate of patients with AP is higher than that of common individuals. And the proportion of patients with severe AP is higher in the patients with positive HCMV-IgM. There is a significant difference in the past HCMV infection rate among AP patients with different ages, with different