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中文摘要：
FOXM1是一种增殖相关的促癌转录因子,多个研究证实,FOXM1在包括卵巢癌的多种实体肿瘤中表达增加,研究表明FOXM1通过多种机制参与卵巢癌的发生、发展等生物学过程,与卵巢癌增殖、侵袭、转移,上皮间质转化及耐药等多方面密切相关。未来通过对FOXM1的深入研究,其作用机制将更加明确,FOXM1可作为卵巢癌临床应用及基因治疗的新靶点。
英文摘要：
FOXM1 is a transcription factor related to proliferation. Several studies have confirmed that FOXM1 is overexpression in a variety of solid tumors, including ovarian cancer. Studies have indicated that FOXM1 is involved in the occurrence and development of ovarian cancer through a variety of mechanisms, and is closely related to the prolif- eration,invasion, metastasis, epithelial mesenchymal transition and drug resistance of ovarian cancer. Through deep study of FOXM1, its mechanism will be more clear, and FOXM1 may be a new target for ovarian cancer clinical appli- cations and gene therapy.
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