目的:探讨停用免疫抑制剂对肝移植感染的治疗作用。方法:根据肝移植感染者多器官功能障碍综合征评分停用免疫抑制剂,比较停用免疫抑制剂(观察组)与常规使用免疫抑制剂(常规组)对肝移植感染者抗感染疗程、生存率和排斥反应的影响。结果:肝移植感染者停用免疫抑制剂可缩短抗感染疗程,与常规应用免疫抑制剂比较差异有统计学意义(P〈0.05),并能提高生存率(P〈0.05)而不增加排斥反应率(P〉0.05)。结论:根据多器官功能障碍综合征评分停用免疫抑制剂对肝移植感染者有明显的治疗作用。
Objective To study the therapeutic effects of stopping immunosuppressants on the infections after liver transplantation. Methods Based on multiple organ dysfunction syndrome score, the immunosuppressants were discontinued in the infections after liver transplantation. The influences of stopping immunosuppressants on the anti-infectious treatment course, survival rate and rejection reaction rate were compared between the observation group and the routine group. Results As to the infections after liver transplantation, stopping immunosuppressants shortened the anti-infectious treatment course (P〈0.05), elevated the survival rate(P〈0.05), and did not result in rejection reaction(P 〉 0. 05). Conclusion Stopping the immunosuppressants could benefit the therapy of infection after liver transplantation.