欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的 观察2型糖尿病患者的小肠绒毛形态变化对其血糖的影响。方法 收集2型糖尿病患者12例（观察组）,非糖尿病患者12例（对照组）和健康体检者8例（正常组）,入组患者均接受胶囊内镜检查,记录比较两组患者的胃通过时间（GTT）、小肠通过时间（SBTT）、全小肠完成率（CR）、Lewis评分、阳性病变率、临床症状、C反应蛋白（CRP）、随机血糖（RBS）和糖化血红蛋白（Hb A1c）变化情况。结果 与对照组和正常组相比,观察组患者的GTT和SBTT延长,小肠绒毛评分和阳性病变率、CRP、RBS和Hb A1c水平以及腹泻和便秘发生率均较高;统计显示2型糖尿病患者的SBTT与便秘和Lewis评分均正相关,Lewis评分与Hb A1c呈正相关。结论 2型糖尿病患者存在不同程度的小肠绒毛病变及功能紊乱,推测长期血糖控制不佳是重要原因。
英文摘要：
[ Objective ] To observe the effect of morphologic change of villi of small intestine on blood glucose of patients with type 2 diabetes mellitus （T2DM）. [ Methods ] Twelve T2DM patients were collected in observation group, another twelve non-DM patients were in control group and eight health people in normal group. All the patients underwent capsule endoscopy （CE）, gastric transit time （GTT）, small bowel transit time （SBTF）, entire small intestine completion rate （CR）, lewis scores, the rates of positive lesions, clinical symptoms, C reactive protein （CRP）, random blood sugar （RBS） and hemoglobin Alc （HbAlc） of patients in two groups were recorded and compared. [ Results ] In compared with control group and normal group, the GTT and SBTF were prolonged, the scores of intestinal villus, serum CRP level, the rates of positive lesions, the levels of RBS and HbAlc, and the incidences of diarrhea and constipation were higher of patients in observation group. The statistics showed that T2DM patients SBTT had positive relationship with constipation and lewis scores, and lewis scores had a positive correlation with glycosylated hemoglobin. [ Conclusion ] Different degrees of intestinal functional disorder and villus damage have happened in patients with T2DM, we suppose that the bad blood glucose control in long-term is an important reason.
同期刊论文项目
同项目期刊论文
期刊信息
位置：